Journal article
Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies
A Yap, MA Lopez-Olivo, J Dubowitz, G Pratt, J Hiller, V Gottumukkala, E Sloan, B Riedel, R Schier
British Journal of Anaesthesia | ELSEVIER SCI LTD | Published : 2018
Abstract
Background: The biological perturbation associated with psychological and surgical stress is implicated in cancer recurrence. Preclinical evidence suggests that beta-blockers can be protective against cancer progression. We undertook a meta-analysis of epidemiological and perioperative clinical studies to investigate the association between beta-blocker use and cancer recurrence (CR), disease-free survival (DFS), and overall survival (OS). Methods: Databases were searched until September 2017, reported hazard ratios (HRs) pooled, and 95% confidence intervals (CIs) calculated. Comparative studies examining the effect of beta-blockers (selective and non-selective) on cancer outcomes were inclu..
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Grants
Awarded by Rheumatology Research Foundation
Funding Acknowledgements
National Health and Medical Research Council of Australia (1147498), the Australian and New Zealand College of Anaesthetists (17/003), and the David and Lorelle Skewes Foundation. Career award from the Rheumatology Research Foundation, USA to M. L.-O.